Visible light promoted hydration of alkynes catalyzed by rhodium(III) porphyrins.

Visible light promoted hydration of a wide scope of alkynes to ketones catalyzed by rhodium(III) porphyrin complexes was described. The key intermediate ß-carbonyl alkyl was observed and independently synthesized. The rate of photolysis is over two orders of magnitude faster than that of the thermal process.

Effect of pharmaceutical care on medication adherence and hospital admission in patients with chronic obstructive pulmonary disease (COPD): a randomized controlled study.

BACKGROUND: Poor adherence leads to a high rate of exacerbation and poor health-related quality of life (HRQoL) in patients with chronic obstructive pulmonary disease (COPD). However, few strategies are acceptable and effective in improving medication adherence. We investigated whether pharmaceutical care by clinical pharmacists could reinforce medication adherence to reduce exacerbation and improve HRQoL. METHODS: A randomized controlled study was carried out at The First Affiliated Hospital of Guangzhou Medical University from February 2012 to January 2014. Non-adherence patients were randomly assigned to receive pharmaceutical care or to usual care. The pharmaceutical care consisted of individualized education and a series of telephone counseling for 6 months provided by clinical pharmacists. Medication adherence was measured by pill counts plus direct interview at 1- and 6-month pharmaceutical care and one-year follow-up. Severe exacerbations were defined as events that led to hospitalization for acute COPD attack. An interview was conducted to investigate hospital admissions and evaluate severe exacerbations at one-year follow-up. HRQoL was measured by St George's Respiratory Questionnaire at 6 months. RESULTS: At 6-month pharmaceutical care and one-year follow-up, the pharmaceutical care group exhibited higher medication adherence than the usual care group (73.4±11.1 vs. 55.7±11.9, P=0.016 and 54.4±12.5 vs. 66.5±8.6, P=0.039, respectively). There are 60 acute exacerbations resulted in a hospital admission in the usual group while 37 ones in the pharmaceutical care group during one-year follow-up (P=0.01). Hospital admissions due to acute exacerbation in the pharmaceutical care group were 56.3% less than the usual care group (P=0.01). There was a significant difference in the symptoms and impact subscales respectively at 6-month pharmaceutical care between two groups (P=0.032, P=0.018). CONCLUSIONS: Individualized pharmaceutical care improved medication adherence, reduced hospitalization and elevated HRQoL in patients with COPD.

Aerobic oxidative N-dealkylation of tertiary amines in aqueous solution catalyzed by rhodium porphyrins.

Aerobic oxidative N-dealkylation of a variety of aliphatic tertiary amines and anilines catalyzed by rhodium(III) tetra (p-sulfonatophenyl) porphyrin ((TSPP)Rh(III)) is achieved in aqueous solution using dioxygen as the sole oxidant.

Azobisisobutyronitrile initiated aerobic oxidative transformation of amines: coupling of primary amines and cyanation of tertiary amines.

In the presence of a catalytic amount of radical initiator AIBN, primary amines are oxidatively coupled to imines and tertiary amines are cyanated to α-aminonitriles. These "metal-free" aerobic oxidative coupling reactions may find applications in a wide range of "green" oxidation chemistry.

Metal-free aerobic oxidative coupling of amines to imines.

Oxidative coupling of primary amines to imines is achieved with high to moderate yields by refluxing suspensions of amines and water under one atmosphere dioxygen without any additives. Tandem acid-free aza Diels-Alder reactions for synthesis of N-alkyl-4-pyridones are also accomplished.

Aerobic oxidation of alcohols catalyzed by rhodium(III) porphyrin complexes in water: reactivity and mechanistic studies.

Selective oxidation of alcohol in water using molecular oxygen as the terminal oxidant is mediated by rhodium porphyrin complexes. Addition of methanol to an aqueous solution of (TSPP)Rh(III) resulted in observation of the key intermediate porphyrin rhodium(III) methoxide species. The activation parameters for betaC-H elimination of Rh-alkoxide were evaluated.

Nanosized gradient pi-conjugated thienylethynylene dendrimers for light harvesting: synthesis and properties.

[reaction: see text] A family of pi-conjugated dendrimers based on truxene and thienylethynylene units are synthesized via a mixed divergent/convergent growth approach. These dendrimers possess an intrinsic energy gradient from the periphery to the core through branches and thus show a broad absorption in the UV-vis range and an efficient energy transfer to the lower-energy center. The molecules hence have the potential to be used as light harvesting materials.